Interaction between vascularized lymph node transfer and recipient lymphatics after lymph node dissection- a pilot study in a canine model
Identifieur interne : 000F48 ( Main/Exploration ); précédent : 000F47; suivant : 000F49Interaction between vascularized lymph node transfer and recipient lymphatics after lymph node dissection- a pilot study in a canine model
Auteurs : Hiroo Suami [États-Unis] ; Mario F. Scaglioni [États-Unis] ; Katherine A. Dixon [États-Unis] ; Ramesh C. Tailor [États-Unis]Source :
- The Journal of surgical research [ 0022-4804 ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
- effets indésirables : Lymphadénectomie, Radiothérapie.
- étiologie : Lymphoedème, Noeuds lymphatiques.
- Animaux, Chiens, Femelle, Lambeaux chirurgicaux, Lymphangiogenèse, Lymphoedème, Modèles animaux, Projets pilotes.
English descriptors
- KwdEn :
- MESH :
- adverse effects : Lymph Node Excision, Radiotherapy.
- blood supply : Surgical Flaps.
- etiology : Lymphedema.
- surgery : Lymphedema.
- transplantation : Lymph Nodes.
- Animals, Dogs, Female, Lymphangiogenesis, Models, Animal, Pilot Projects.
Abstract
Vascularized lymph node transfer (VLNT) has become more wide-spread for surgical treatment of lymphedema. However, interaction between a transferred lymph node and the recipient lymphatic system in relieving lymphedema has not been identified. The aims of this study were to investigate anatomical changes in the lymphatic system in the forelimb of a canine after lymph node dissection and irradiation and to clarify the interaction between the transferred lymph node and recipient lymphatics.
Two adult female mongrel canines were used for this exploratory study. The unilateral axillary and lower neck node dissections were performed, and 15-Gy irradiation was applied on postoperative day three. After one year, a VLNT flap was harvested from the lower abdominal region and inset in the axilla with vascular anastomoses. The girth of each forelimb was determined with a tape measure at different time points. Indocyanine green fluorescence lymphography and lymphangiography were performed before and after each surgery to evaluate morphological changes in the lymphatics.
Both canines revealed identical changes in the lymphatic system but only one canine developed lymphedema. After lymph node dissection, a collateral lymphatic pathway formed a connection to the contralateral cervical node. After VLNT, an additional collateral pathway formed a connection to the internal mammary node via the transferred node in the axilla.
The findings suggest that the lymphatic system has a homing mechanism, which allows the severed lymphatic vessels to detect and connect to adjacent lymph nodes. VLNT may create new collateral pathways to relieve lymphedema.
Url:
DOI: 10.1016/j.jss.2016.05.029
PubMed: 27565078
PubMed Central: 5002893
Affiliations:
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Le document en format XML
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Scaglioni</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Dixon, Katherine A" sort="Dixon, Katherine A" uniqKey="Dixon K" first="Katherine A." last="Dixon">Katherine A. Dixon</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, Texas</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Tailor, Ramesh C" sort="Tailor, Ramesh C" uniqKey="Tailor R" first="Ramesh C." last="Tailor">Ramesh C. Tailor</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston</wicri:cityArea></affiliation></author></analytic><series><title level="j">The Journal of surgical research</title><idno type="ISSN">0022-4804</idno><idno type="eISSN">1095-8673</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Dogs</term><term>Female</term><term>Lymph Node Excision (adverse effects)</term><term>Lymph Nodes (transplantation)</term><term>Lymphangiogenesis</term><term>Lymphedema (etiology)</term><term>Lymphedema (surgery)</term><term>Models, Animal</term><term>Pilot Projects</term><term>Radiotherapy (adverse effects)</term><term>Surgical Flaps (blood supply)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Chiens</term><term>Femelle</term><term>Lambeaux chirurgicaux ()</term><term>Lymphadénectomie (effets indésirables)</term><term>Lymphangiogenèse</term><term>Lymphoedème ()</term><term>Lymphoedème (étiologie)</term><term>Modèles animaux</term><term>Noeuds lymphatiques (transplantation)</term><term>Projets pilotes</term><term>Radiothérapie (effets indésirables)</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Lymph Node Excision</term><term>Radiotherapy</term></keywords><keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Surgical Flaps</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Lymphadénectomie</term><term>Radiothérapie</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="transplantation" xml:lang="en"><term>Lymph Nodes</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Lymphoedème</term><term>Noeuds lymphatiques</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Dogs</term><term>Female</term><term>Lymphangiogenesis</term><term>Models, Animal</term><term>Pilot Projects</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Chiens</term><term>Femelle</term><term>Lambeaux chirurgicaux</term><term>Lymphangiogenèse</term><term>Lymphoedème</term><term>Modèles animaux</term><term>Projets pilotes</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P2">Vascularized lymph node transfer (VLNT) has become more wide-spread for surgical treatment of lymphedema. However, interaction between a transferred lymph node and the recipient lymphatic system in relieving lymphedema has not been identified. The aims of this study were to investigate anatomical changes in the lymphatic system in the forelimb of a canine after lymph node dissection and irradiation and to clarify the interaction between the transferred lymph node and recipient lymphatics.</p></sec><sec id="S2"><title>Materials and Methods</title><p id="P3">Two adult female mongrel canines were used for this exploratory study. The unilateral axillary and lower neck node dissections were performed, and 15-Gy irradiation was applied on postoperative day three. After one year, a VLNT flap was harvested from the lower abdominal region and inset in the axilla with vascular anastomoses. The girth of each forelimb was determined with a tape measure at different time points. Indocyanine green fluorescence lymphography and lymphangiography were performed before and after each surgery to evaluate morphological changes in the lymphatics.</p></sec><sec id="S3"><title>Results</title><p id="P4">Both canines revealed identical changes in the lymphatic system but only one canine developed lymphedema. After lymph node dissection, a collateral lymphatic pathway formed a connection to the contralateral cervical node. After VLNT, an additional collateral pathway formed a connection to the internal mammary node via the transferred node in the axilla.</p></sec><sec id="S4"><title>Conclusions</title><p id="P5">The findings suggest that the lymphatic system has a homing mechanism, which allows the severed lymphatic vessels to detect and connect to adjacent lymph nodes. VLNT may create new collateral pathways to relieve lymphedema.</p></sec></div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Texas</li></region></list><tree><country name="États-Unis"><region name="Texas"><name sortKey="Suami, Hiroo" sort="Suami, Hiroo" uniqKey="Suami H" first="Hiroo" last="Suami">Hiroo Suami</name></region><name sortKey="Dixon, Katherine A" sort="Dixon, Katherine A" uniqKey="Dixon K" first="Katherine A." last="Dixon">Katherine A. Dixon</name><name sortKey="Scaglioni, Mario F" sort="Scaglioni, Mario F" uniqKey="Scaglioni M" first="Mario F." last="Scaglioni">Mario F. Scaglioni</name><name sortKey="Tailor, Ramesh C" sort="Tailor, Ramesh C" uniqKey="Tailor R" first="Ramesh C." last="Tailor">Ramesh C. Tailor</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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